A genome-wide scan for obesity in African-Americans.

A Genome-Wide Breast Cancer Scan in African Americans

Copy number variations associated with obesity related traits in African Americans: a joint analysis between GENOA and HyperGEN

Obesity is a highly heritable trait and a growing public health problem. African Americans (AAs) are a genetically diverse, yet understudied population with a high prevalence of obesity (BMI >30 kg/m(2)). Recent studies based upon single-nucleotide polymorphisms (SNPs) have identified genetic markers associated with obesity. However, a large proportion of the heritability of obesity remains une...

Admixture Mapping and Subsequent Fine-Mapping Suggests a Biologically Relevant and Novel Association on Chromosome 11 for Type 2 Diabetes in African Americans

Type 2 diabetes (T2D) is a complex metabolic disease that disproportionately affects African Americans. Genome-wide association studies (GWAS) have identified several loci that contribute to T2D in European Americans, but few studies have been performed in admixed populations. We first performed a GWAS of 1,563 African Americans from the Vanderbilt Genome-Electronic Records Project and Northwes...

TITLE: A Genome-wide Breast Cancer Scan in African Americans PRINCIPAL INVESTIGATOR:

s/Posters: “Towards Understanding Breast Cancer Susceptibility in Women of African Ancestry”, Department of Defense Congressionally Directed Breast Cancer Research Program, Era of Hope, 2011. “Genome-wide association studies identify novel ER-negative specific breast cancer risk loci”, American Society of Human Genetics, 2012.

Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.

Insulin resistance (IR) is a key determinant of type 2 diabetes (T2D) and other metabolic disorders. This genome-wide association study (GWAS) was designed to shed light on the genetic basis of fasting insulin (FI) and IR in 927 non-diabetic African Americans. 5 396 838 single-nucleotide polymorphisms (SNPs) were tested for associations with FI or IR with adjustments for age, sex, body mass ind...